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A group that has not yet benefitted from these global and regional HIV trends is young women. Adolescent girls and young women acquire HIV infection 5-7 years before men. This age-sex difference in HIV acquisition is a major driver of new HIV infections despite unprecedentedly high HIV prevalence. There remains a knowledge gap in women initiated prevention technologies and interventions for this critical group of young women. The potential for ARV based vaginal microbicides, PrEP and passive immunity offer hope for young women but are several years away. It is therefore crucial that clinical trials include adolescent women towards an AIDS-free generation. 1e1e36bf2d